The Familiar Made Unfamiliar.

 

It may take a couple of seconds to realise it, but this is one of the most famous artworks in history.

Being subject to an in-situ (naturally) conservation. This is probably a section of the 1978-1999 major restoration.

Since the painting of the original, there have been many parodies, copies, derivative works and inspirations. My favourite occurs quietly in the film M*A*S*H

Bonus -